A comprehensive review on plasmonic-based biosensors used in viral diagnostics

Commun Biol. 2021 Jan 15;4(1):70. doi: 10.1038/s42003-020-01615-8.


The proliferation and transmission of viruses has become a threat to worldwide biosecurity, as exemplified by the current COVID-19 pandemic. Early diagnosis of viral infection and disease control have always been critical. Virus detection can be achieved based on various plasmonic phenomena, including propagating surface plasmon resonance (SPR), localized SPR, surface-enhanced Raman scattering, surface-enhanced fluorescence and surface-enhanced infrared absorption spectroscopy. The present review covers all available information on plasmonic-based virus detection, and collected data on these sensors based on several parameters. These data will assist the audience in advancing research and development of a new generation of versatile virus biosensors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • COVID-19 / diagnosis*
  • COVID-19 / epidemiology*
  • COVID-19 / virology
  • Humans
  • Nanostructures / chemistry
  • Pandemics*
  • SARS-CoV-2 / chemistry*
  • Spectrometry, Fluorescence / methods
  • Spectrophotometry, Infrared / methods
  • Spectrum Analysis, Raman / methods*
  • Surface Plasmon Resonance / methods*