CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Commun Biol. 2021 Jan 15;4(1):73. doi: 10.1038/s42003-020-01591-z.


Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of the preB cell receptor (preBCR), to be associated with CNS-infiltration and -relapse in B-cell precursor (BCP)-ALL patients. Furthermore, we show that downregulation of CD79a hampers the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CD79 Antigens / metabolism*
  • Cell Line, Tumor
  • Central Nervous System Neoplasms / metabolism*
  • Humans
  • Mice
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Xenograft Model Antitumor Assays
  • src-Family Kinases / metabolism*


  • CD79 Antigens
  • CD79A protein, human
  • src-Family Kinases