TBK1 (TANK-binding kinase 1)-mediated regulation of autophagy in health and disease

Matrix Biol. 2021 Jun:100-101:84-98. doi: 10.1016/j.matbio.2021.01.004. Epub 2021 Jan 14.


TANK-binding kinase 1 (TBK1) is a druggable multifunctional kinase that exerts a broad spectrum of functions in cells. These range from innate immunity, inflammation and interferon (IFN) signaling, through selective autophagy, specifically mitophagy and xenophagy, to energy homeostasis. Thus, it is not surprising that TBK1 is involved in many cellular signaling pathways that contribute to diverse pathologies. In this review the role of TBK1 in autophagic signaling, especially mitophagy and xenophagy, and its contribution to oncogenesis or neurodegenerative diseases will be discussed.

Keywords: Autophagy; Cancer; Mitophagy; Neurodegeneration; TBK1; Xenophagy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autophagy*
  • Humans
  • Immunity, Innate
  • Inflammation
  • Protein Serine-Threonine Kinases / genetics
  • Signal Transduction*


  • Protein Serine-Threonine Kinases
  • TBK1 protein, human