Thiol-Disulfide Homeostasis in Neonatal Patients with Urinary Tract Infection

Am J Perinatol. 2022 Oct;39(13):1460-1464. doi: 10.1055/s-0040-1722656. Epub 2021 Jan 17.


Objective: Urinary tract infection (UTI) is a disease that can cause significant complications in the neonatal period. The thiol-disulfide homeostasis is one of the important antioxidant defense mechanisms. The purpose of this study is to show the relationship between UTI and thiol-disulfide homeostasis in newborns.

Study design: In this prospective study, 40 newborns with UTI and 40 healthy controls were included. Thiol-disulfide tests (disulfide, native thiol, and total thiol levels) and septic screening tests were performed before and after antibiotherapy in UTI group. The control group was selected from healthy newborns who applied to the outpatient clinic.

Results: The C-reactive protein and interleukin-6 levels were higher, while native thiol and native thiol/total thiol ratio were significantly lower in pretreatment group compared with posttreatment and control group. Also, the levels of disulfide, ischemia modified albumin, disulfide/native thiol ratio, and disulfide/total thiol ratio were higher in pretreatment group compared with posttreatment group.

Conclusion: The thiol-disulfide homeostasis is an important indicator of oxidative stress during infections. It is valuable to be detected with small amounts of serum in newborns. These molecules can be used to support the diagnosis of UTI in the newborn. Further studies are needed to define the role of thiol-disulfide homeostasis in the UTI of newborn.

Key points: · The thiol-disulfide homeostasis can be an important indicator of oxidative stress during infections such as UTI.. · The thiol-disulfide homeostasis of newborn is valuable to be detected with small amounts of serum in neonatal period.. · Laboratory tests such as white blood cell count, erythrocyte sedimentation rate, and C-reactive protein are not significantly different in UTIs..

MeSH terms

  • Antioxidants / metabolism
  • Biomarkers
  • C-Reactive Protein / metabolism
  • Disulfides*
  • Homeostasis
  • Humans
  • Infant, Newborn
  • Interleukin-6
  • Oxidative Stress
  • Prospective Studies
  • Serum Albumin / metabolism
  • Sulfhydryl Compounds
  • Urinary Tract Infections*


  • Antioxidants
  • Biomarkers
  • Disulfides
  • Interleukin-6
  • Serum Albumin
  • Sulfhydryl Compounds
  • C-Reactive Protein