Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

J Oral Pathol Med. 2021 Sep;50(8):741-749. doi: 10.1111/jop.13159. Epub 2021 Feb 18.


Background: The aim of the present systematic review was to analyze the available data regarding acinic cell carcinoma of the oral and maxillofacial region.

Methods: A search strategy was performed using PubMed, Web of Science, Scopus, and Embase electronic databases.

Results: Available data revealed a slight female preference (54.73%) and a mean age at diagnosis of 47.51 ± 19.85 years. The parotid glands (67.72%) were most frequently affected, and most cases were asymptomatic (69.54%). A microcystic histopathological pattern was reported in 21.56% of the cases, and the Periodic acid-Schiff was the staining method most frequently used, after the hematoxylin and eosin staining, in the tumors analyzed. The lesions were mainly treated by surgical removal (72.32%). Recurrence was reported in 81 cases (27.83%) and metastasis in 100 (42.91%). Statistical data analysis revealed that tumors located in major salivary glands and exhibiting high-grade histology were associated with local recurrence (P = .01). In addition, the patients older than 57 years, lesions with bone involvement, the high-grade tumors and the cases with a history of recurrence and metastasis were associated with a lower overall survival (P < .05).

Conclusion: By assembling all eligible cases in the literature, the present systematic review determined the most common clinicopathological profile of acinic cell carcinoma and the most relevant prognostic factors in a distinctly representative sample. The survey demonstrated the importance of considering the histopathological grading in order to better define the treatment for each case.

Keywords: acinar cell carcinoma; mouth neoplasms; salivary glands neoplasms.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Carcinoma, Acinar Cell* / surgery
  • Female
  • Humans
  • Neoplasm Recurrence, Local
  • Parotid Gland
  • Salivary Gland Neoplasms* / surgery
  • Salivary Glands