Statin-induced necrotizing autoimmune myopathy

Proc (Bayl Univ Med Cent). 2020 Oct 21;34(1):185-186. doi: 10.1080/08998280.2020.1831298.


Statins are the most widely used class of drug in the United States. They lower blood cholesterol levels by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase. Common side effects include myalgias and a mild increase in liver function tests. Statin-induced necrotizing autoimmune myopathy (SINAM) is a very rare side effect that is independent of the type and duration of statin use. Treatment involves high-dose steroids and immunosuppressants such as azathioprine, methotrexate, or mycophenolate mofetil. Nonresponders and patients with severe weakness can be treated with intravenous immunoglobulin or rituximab. We present a case of SINAM that was successfully treated with intravenous immunoglobulin.

Keywords: Immunosuppressants; SINAM; rhabdomyolysis; statin-induced necrotizing autoimmune myopathy; statins.

Publication types

  • Case Reports