Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis

J Dermatol. 2021 Mar;48(3):344-352. doi: 10.1111/1346-8138.15703. Epub 2021 Jan 17.


SR-T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B-induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR-T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16-week SR-T100 gel treatment were documented. SR-T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR-T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR-T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR-T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.

Keywords: Solanum undatum; actinic keratosis; photoaging; photocarcinogenesis; solamargine.

MeSH terms

  • Animals
  • Keratosis, Actinic* / drug therapy
  • Mice
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Skin Aging*
  • Solanum*


  • Plant Extracts
  • SR-T100