Effect of glycolic acid, phytic acid, soothing complex containing Emulsion on Hyperpigmentation and skin luminosity: A clinical evaluation

J Cosmet Dermatol. 2021 Mar;20(3):776-780. doi: 10.1111/jocd.13950. Epub 2021 Feb 2.


Background: Improvement in skin luminosity and dyschromia such as postinflammatory hyperpigmentation (PIH) and actinic photodamage are leading causes for cosmetic consultation. Formulation of topical at home treatment is challenging, using a range of modalities, to help hinder or prevent inflammatory mediators without further irritating the skin. Glycolic acid is a known antioxidant; in various free acid levels, it has been introduced as a topical therapy aimed at reducing pigmentation and improving skin texture, tone, and luminosity.

Methods: In a 12-week clinical study, a novel, topical facial emulsion containing 10% glycolic acid, 2% phytic acid, and soothing complex in emulsion was evaluated for its effectiveness in treating skin quality in American female volunteers with Fitzpatrick skin types II-VI. Efficacy evaluations were performed at pretreatment baseline, weeks 2, 4, 8, and 12, and included expert clinical grading, and self-assessment questionnaires. Cutaneous tolerability was also evaluated by assessing subjective and objective irritation of the treatment area.

Results: Significant improvement in the appearance of skin PIH, hyperpigmentation, texture, and tone homogeneity was observed beginning at week 4 and continued through week 12.

Conclusions: The findings suggest that the test product is well suited for at-home skincare. It was both well-tolerated and an effective treatment option for addressing hyperpigmentation and overall skin luminosity.

Keywords: actinic photodamage; glycolic acid; hyperpigmentation; luminosity.

MeSH terms

  • Emulsions
  • Female
  • Glycolates / therapeutic use
  • Humans
  • Hyperpigmentation* / chemically induced
  • Hyperpigmentation* / drug therapy
  • Phytic Acid*
  • Treatment Outcome


  • Emulsions
  • Glycolates
  • glycolic acid
  • Phytic Acid