Neurodevelopmental and Neurodegenerative Similarities and Interactions: A Point of View About Lifelong Neurocognitive Trajectories

J Alzheimers Dis. 2021;79(4):1397-1407. doi: 10.3233/JAD-201207.

Abstract

Neurodevelopmental and neurodegenerative disorders are both growing major public health topics with similarities and frequent complex interactions with each other. Taking these aspects into account can provide a new point of view on lifelong neurocognitive trajectories. Assessing both neurodevelopmental and neurodegenerative dimensions during cognitive and behavioral clinical assessments is challenging but might improve diagnostic accuracy and physiopathological understanding. It is therefore necessary to understand the lifelong specific neurocognitive trajectory of each patient in order to develop personalized precision cognitive medicine.

Keywords: Atypical dementia; neurodegenerative disorders; neurodevelopmental disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Neurodegenerative Diseases*
  • Neurodevelopmental Disorders*