Papillary neoplasms of the breast-reviewing the spectrum

Mod Pathol. 2021 Jun;34(6):1044-1061. doi: 10.1038/s41379-020-00732-3. Epub 2021 Jan 18.


Papillary neoplasms of the breast encompass a wide range of tumor types ranging from the benign intraductal papilloma to in situ and invasive papillary carcinomas. In this review, we considered each tumor entity listed under the Papillary Neoplasms category in the latest WHO Classification of Breast Tumors (5th edition), namely intraductal papilloma, papillary ductal carcinoma in situ, encapsulated papillary carcinoma, solid-papillary carcinoma, and invasive papillary carcinoma. We examined their pathological features, current issues pertaining to diagnosis and prognostication, as well as the latest molecular findings. We also briefly addressed adenomyoepithelioma and the newly included tall cell carcinoma with reversed polarity, highlighting areas where they overlap with papillary neoplasms.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / pathology*
  • Carcinoma, Intraductal, Noninfiltrating / pathology
  • Carcinoma, Papillary / pathology*
  • Female
  • Humans