The Outcome of Accidental Bacille Calmette-Guérin Overdose During Routine Neonatal Immunization

Pediatr Infect Dis J. 2021 Jun 1;40(6):588-589. doi: 10.1097/INF.0000000000003073.

Abstract

We report a retrospective study on outcome of 14 newborn infants who received 62.5 times the recommended dose of Bacille Calmette-Guérin for immunization. All infants then received high-dose isoniazid and rifampicin (20 mg/kg/d each) as preventive therapy for 6 months. All had mild local adverse reactions, a third resolving within 16 weeks and all by 6 months.

MeSH terms

  • Accidents
  • Anti-Bacterial Agents
  • BCG Vaccine / administration & dosage*
  • BCG Vaccine / adverse effects*
  • Drug-Related Side Effects and Adverse Reactions
  • Humans
  • Infant, Newborn
  • Isoniazid / therapeutic use
  • Retrospective Studies
  • Rifampin / therapeutic use
  • Tuberculosis / drug therapy
  • Tuberculosis / prevention & control*
  • Vaccination / adverse effects*

Substances

  • Anti-Bacterial Agents
  • BCG Vaccine
  • Isoniazid
  • Rifampin