Six complementation groups for ionising-radiation sensitivity in Chinese hamster cells

Mutat Res. 1988 Mar;193(2):139-44. doi: 10.1016/0167-8817(88)90044-2.

Abstract

The ionising radiation-sensitive mutants irs 1, irs 2, irs 3, xrs-1 (or xrs-7), EM7 and XR-1 were fused to wild-type cells or to each other in pairs to create hybrid cells. These hybrids were checked chromosomally and their X-ray sensitivity tested. Each mutant was found to be recessive to wild-type and to complement the X-ray sensitivity of the other mutants. Thus there appear to be at least 6 complementation groups for ionising radiation sensitivity in Chinese hamster cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Fusion / radiation effects
  • Cell Line
  • Cricetinae
  • Cricetulus
  • Crosses, Genetic
  • Genes, Recessive
  • Genetic Complementation Test*
  • Hybrid Cells / radiation effects*
  • Mutation
  • Phenotype
  • X-Rays