Umbilical Cord Management in Late Preterm and Term Infants: A Randomized Controlled Trial

Am J Perinatol. 2022 Sep;39(12):1308-1313. doi: 10.1055/s-0040-1722327. Epub 2021 Jan 20.


Objective: The study aimed to compare the effects of three different methods of umbilical cord management on hematological parameters in term and late-preterm infants.

Study design: A randomized controlled trial comparing intact-umbilical cord milking (I-UCM) with cut-umbilical cord milking (C-UCM) and immediate cord clamping (ICC) in neonates born >35 weeks' gestation.

Results: A total of 587 infants were evaluated. Of these, 197 were assigned to I-UCM, 190 to C-UCM, and 200 to ICC. Mean hemoglobin and hematocrit levels at 48 hours of age were higher in I-UCM group compared with the ICC group (p = 0.002 and p = 0.010, respectively).

Conclusion: These findings suggest that I-UCM is more beneficial choice. Further trials are needed to assess the various long- and short-term effects of different cord milking methods.

Key points: · This is the first study comparing these three methods (I-UCM, C-UCM, and ICC) concurrently.. · I-UCM is more beneficial choice.. · Although the terms I-UCM and C-UCM are often used interchangeably, these are different procedures..

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Constriction
  • Gestational Age
  • Hemoglobins / analysis
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature*
  • Umbilical Cord* / chemistry


  • Hemoglobins