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. 2021 Jan 20;21(1):60.
doi: 10.1186/s12935-021-01751-z.

Conditional survival after surgical resection of primary retroperitoneal tumors: a population-based study

Shutao Zhao  1 , Yixuan Zhao  1 , Shuang Liu  1 , Chao Zhang  1 , Xudong Wang  2
Affiliations

Conditional survival after surgical resection of primary retroperitoneal tumors: a population-based study

Shutao Zhao et al. Cancer Cell Int. .

Abstract

Background: The purpose of this study was to assess conditional survival (CS) after resection of primary retroperitoneal tumors (RPTs).

Methods: The data of 1594 patients with primary RPTs who underwent surgery between 2004 and 2016 were retrieved from the Surveillance Epidemiology and End Results (SEER) database. Multivariate Cox analysis was used to identify prognostic factors affecting overall survival (OS) and cancer-specific survival (CSS). CS was used to calculate the probability of survival for an additional 3 years after the patient had survived x years, according to the formulas: COS3 = OS (x + 3) /OS (x) and CCSS3 = CSS (x + 3)/CSS (x).

Results: The 1-, 3-, and 5-year OS rates of all patients were 89.8, 71.8, and 60.8%, while the 1-, 3-, and 5-year CSS rates were 91.9, 77.1, and 67.8%, respectively. Age, sex, FNCLCC grade, size, multifocality, histology, and chemotherapy were independent prognostic factors for OS and CSS. Among patients who survived for 1, 3, and 5 years, the COS3 rates were 72.9, 77.9, and 79.3%, and the CCSS3 rates were 78.1, 82.7, and 85.8%, respectively. Patients with poor clinicopathological characteristics achieved greater improvements in COS3 and CCSS3 rates, and the survival gaps between OS and COS3, as well as CSS and CCSS3 were more obvious.

Conclusion: Postoperative CS of RPTs was dynamic and increased over time. CS increased more significantly in patients with poor clinicopathological characteristics.

Keywords: Conditional survival; Dynamic assessment; Primary retroperitoneal tumors; Prognosis.

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Conflict of interest statement

The authors report no competing interest in this study.

Figures

Fig. 1
Fig. 1
Flowchart of the selection process of included patients
Fig. 2
Fig. 2
Kaplan–Meier survival curve of overall survival (a) and cancer-specific survival (c); hazard estimates of death from any reason (b) or primary retroperitoneal tumors (d) are illustrated for all patients in the cohort
Fig. 3
Fig. 3
a Conditional overall survival relative to actual overall survival; b Conditional cancer-specific survival relative to actual cancer-specific survival
Fig. 4
Fig. 4
Actual overall survival stratified by: a age, c sex, e marital status, and g FNCLCC grade vs conditional overall survival relative to actual survival stratified by: b age, d sex, f marital status, and h ENETs NFNCLCC grade
Fig. 5
Fig. 5
Actual overall survival stratified by: a multifocality, c chemotherapy, e size, and g histology vs conditional overall survival relative to actual survival stratified by: b multifocality, d chemotherapy, f size, and h histology
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References

    1. Management of primary retroperitoneal sarcoma (RPS) in the adult: a consensus approach from the Trans-Atlantic RPS Working Group. Ann Surg Oncol. 2015;22(1):256–263. - PubMed
    1. Dangoor A, Seddon B, Gerrand C, Grimer R, Whelan J, Judson I. UK guidelines for the management of soft tissue sarcomas. Clin Sarcoma Res. 2016;6:20. doi: 10.1186/s13569-016-0060-4. - DOI - PMC - PubMed
    1. Matsumoto S. Changes in the diagnosis and treatment of soft tissue sarcoma in Japan, 1977–2016. J Orthop Sci. 2018;23(3):441–448. doi: 10.1016/j.jos.2017.11.019. - DOI - PubMed
    1. Toulmonde M, Bonvalot S, Ray-Coquard I, et al. Retroperitoneal sarcomas: patterns of care in advanced stages, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group. Ann Oncol. 2014;25(3):730–734. doi: 10.1093/annonc/mdt576. - DOI - PMC - PubMed
    1. Callegaro D, Miceli R, Mariani L, Raut CP, Gronchi A. Soft tissue sarcoma nomograms and their incorporation into practice. Cancer. 2017;123(15):2802–2820. doi: 10.1002/cncr.30721. - DOI - PubMed

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