Acute ANCA Vasculitis and Asymptomatic COVID-19

Pediatrics. 2021 Apr;147(4):e2020033092. doi: 10.1542/peds.2020-033092. Epub 2021 Jan 20.

Abstract

We describe the presentation and diagnosis of a child with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis and associated diffuse alveolar hemorrhage who was positive for coronavirus disease 2019 immunoglobulin G antibodies, indicative of a previous asymptomatic infection. Results of multiple polymerase chain reaction tests coinciding with the start of symptoms were negative, indicating that acute infection was not the cause of the patient's symptoms. Coronavirus disease 2019-induced autoimmune diseases have been described in adults, but this case report represents the first case described in a pediatric patient.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / diagnosis
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / etiology*
  • Asymptomatic Diseases*
  • COVID-19 / complications*
  • Child
  • Female
  • Humans