MRI Mapping of Renal T1: Basic Concept

Stefanie J Hectors; Philippe Garteiser; Sabrina Doblas; Gwenaël Pagé; Bernard E Van Beers; John C Waterton; Octavia Bane

doi:10.1007/978-1-0716-0978-1_9

MRI Mapping of Renal T₁: Basic Concept

Methods Mol Biol. 2021:2216:157-169. doi: 10.1007/978-1-0716-0978-1_9.

Authors

Stefanie J Hectors^{1

2

3}, Philippe Garteiser⁴, Sabrina Doblas⁴, Gwenaël Pagé⁴, Bernard E Van Beers⁵, John C Waterton⁶, Octavia Bane^{7

8}

Affiliations

¹ BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
³ Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
⁴ Laboratory of Imaging Biomarkers, Centre de Recherche sur l'Inflammation, Inserm UMR 1149, Université de Paris, Paris, France.
⁵ Laboratory of Imaging Biomarkers, Centre de Recherche sur l'Inflammation, Inserm UMR 1149, Université de Paris and AP-HP, Paris, France.
⁶ Division of Informatics Imaging & Data Sciences, Faculty of Biology Medicine & Health, Centre for Imaging Sciences, School of Health Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.
⁷ BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. octavia.bane@mountsinai.org.
⁸ Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. octavia.bane@mountsinai.org.

Abstract

In renal MRI, measurement of the T₁ relaxation time of water molecules may provide a valuable biomarker for a variety of pathological conditions. Due to its sensitivity to the tissue microenvironment, T₁ has gained substantial interest for noninvasive imaging of renal pathology, including inflammation and fibrosis. In this chapter, we will discuss the basic concept of T₁ mapping and different T₁ measurement techniques and we will provide an overview of emerging preclinical applications of T₁ for imaging of kidney disease.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

Keywords: Kidney; Magnetic resonance imaging (MRI); Parametric imaging; Preclinical; T1 mapping.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biomarkers / analysis*
Humans
Image Processing, Computer-Assisted / methods*
Kidney / physiology*
Magnetic Resonance Imaging / methods*
Monitoring, Physiologic / methods*
Software*

Substances

Biomarkers