Bladder irrigation with povidone-iodine prevent recurrent urinary tract infections in neurogenic bladder patients on clean intermittent catheterization

Neurourol Urodyn. 2021 Feb;40(2):672-679. doi: 10.1002/nau.24607. Epub 2021 Jan 21.


Aims: To determine if daily povidone-iodine (PI) bladder irrigation in neurogenic lower urinary tract dysfunction (NLUTD) patients doing clean intermittent catheterization (CIC) can reduce the rate of symptomatic urinary tract infections (UTIs), emergency department (ED) visit for UTIs, and hospitalization for UTIs.

Methods: We prospectively reviewed the records of patients with NLUTD on CIC who had recurrent symptomatic UTIs and who were placed on daily intravesical instillations of PI. This trial was conducted from January 2014 to January 2020 on 119 patients.

Results: After using daily PI bladder irrigation, the rate of symptomatic UTIs was reduced by 99.2% (incidence rate ratio [IRR]: 0.008, 95% confidence interval [CI]: 0.001-0.059; p < .001), the rate of ED visits was reduced by 99.2%% (IRR: 0.008, 95% CI: 0.001-0.059; p < .001), and the rate of inpatient hospitalizations for UTI was reduced by 99.9% (IRR: 0.0008, 95% CI: 0.0002-0.0035; p < .001). There was also a significant decrease in multidrug resistance in UTI organisms with the use of PI bladder instillation.

Conclusions: Daily intravesical PI instillation is a well-tolerated approach to prevent UTIs and related ED visits and hospitalizations in NLUTD patients doing CIC.

Keywords: clean intermittent catheterization; intravesical instillation; neurogenic bladder; povidone-iodine; recurrent; urinary tract infection.

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Humans
  • Incidence
  • Intermittent Urethral Catheterization / adverse effects*
  • Intermittent Urethral Catheterization / methods
  • Male
  • Middle Aged
  • Povidone-Iodine / pharmacology
  • Povidone-Iodine / therapeutic use*
  • Prospective Studies
  • Therapeutic Irrigation / methods*
  • Urinary Bladder, Neurogenic / complications*
  • Urinary Tract Infections / drug therapy*
  • Young Adult


  • Povidone-Iodine