Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of neonates, especially of preterm infants, with high morbidity and mortality. The surviving infants may have digestive tract and neurological sequelae. Therefore, the prevention and treatment of NEC are of great significance in improving survival rate and survival quality of neonates. To provide evidence-based recommendations for management of NEC, the guidelines were developed based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) and the current domestic and overseas studies.
坏死性小肠结肠炎(NEC)是新生儿尤其是早产儿的严重胃肠道疾病，其发病率和病死率高。存活的患儿可能遗留消化系统和神经系统后遗症。因此，防治NEC对提高新生儿存活率及生存质量具有重大意义。该指南基于目前国内外相关研究，采用证据推荐分级评估、制定与评价方法(GRADE)，制定NEC临床诊疗循证指南，旨在为NEC的诊断和防治提供证据和参考。