Lymphocytic interstitial pneumonia of common variable immunodeficiency

Ann Allergy. 1988 Mar;60(3):203-6.


We report the beneficial effect of steroids in a 27-year-old woman with lymphocytic interstitial pneumonitis (LIP) and common variable immunodeficiency (CVID). Exertional dyspnea, x-ray infiltrates, and pulmonary physiologic abnormalities decreased or increased during 3 1/2 years of follow-up in parallel with the administered dose of prednisone. This observation rules out concomitant spontaneous remission as the explanation of steroid-induced improvement of LIP in CVID. Steroid treatment was apparently safe: the frequency and severity of recurrent bronchial infections did not change, although IgG replacement therapy was not provided.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Immunologic Deficiency Syndromes / complications*
  • Lung / pathology
  • Lymphocytes
  • Platelet Count
  • Prednisone / therapeutic use
  • Pulmonary Fibrosis / drug therapy
  • Pulmonary Fibrosis / etiology*
  • Pulmonary Fibrosis / immunology
  • Pulmonary Fibrosis / pathology


  • Prednisone