Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes

Circ Res. 2021 Mar 19;128(6):e102-e120. doi: 10.1161/CIRCRESAHA.119.316547. Epub 2021 Jan 25.

Abstract

[Figure: see text].

Keywords: mass spectrometry; mitochondria; muscular dystrophies; proteomics; sarcolemma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Caveolin 3 / genetics
  • Caveolin 3 / metabolism*
  • Cells, Cultured
  • Humans
  • Lactic Acid / metabolism
  • Loss of Function Mutation
  • Monocarboxylic Acid Transporters / metabolism*
  • Myocytes, Cardiac / metabolism*
  • Myocytes, Cardiac / physiology
  • Protein Binding
  • Sodium / metabolism
  • Sodium-Potassium-Exchanging ATPase / metabolism
  • Symporters / metabolism*

Substances

  • CAV3 protein, human
  • Caveolin 3
  • Monocarboxylic Acid Transporters
  • Symporters
  • monocarboxylate transport protein 1
  • Lactic Acid
  • Sodium
  • Sodium-Potassium-Exchanging ATPase