Whole genome sequence of Corynebacterium kroppenstedtii isolated from a case of recurrent granulomatous mastitis

Charlie Tan; Fang-I Lu; Patryk Aftanas; Kara Tsang; Samira Mubareka; Adrienne Chan; Robert Kozak

doi:10.1016/j.idcr.2020.e01034

Whole genome sequence of Corynebacterium kroppenstedtii isolated from a case of recurrent granulomatous mastitis

IDCases. 2020 Dec 29:23:e01034. doi: 10.1016/j.idcr.2020.e01034. eCollection 2021.

Authors

Charlie Tan¹, Fang-I Lu², Patryk Aftanas³, Kara Tsang⁴, Samira Mubareka^{5

3

6}, Adrienne Chan⁶, Robert Kozak^{5

3}

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON, Canada.
² Division of Pathology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
³ Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
⁴ M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine, McMaster University, Hamilton, Ontario L8S 4K1, Canada.
⁵ Department of Laboratory Medicine and Molecular Diagnostics, Division of Microbiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
⁶ Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Abstract

We describe the case of a 33-year-old woman with recurrent granulomatous mastitis associated with Corynebacterium kroppenstedtii. This organism has been increasingly associated with granulomatous mastitis, specifically the cystic neutrophilic histopathologic variant, although currently there is a paucity both of reported cases and genomic sequence data. We highlight the challenges in the diagnosis and treatment of this entity, in particular focusing on the various methods of microbiologic identification, including MALDI-TOF, 16 s rRNA PCR and whole-genome sequencing.

Keywords: Corynebacterium; Whole-genome sequencing.

Publication types

Case Reports