Synthesis of Vinylic Sulfones in Aqueous Media

Org Lett. 2021 Feb 5;23(3):1060-1065. doi: 10.1021/acs.orglett.0c04257. Epub 2021 Jan 25.

Abstract

A green method for the sulfination of allenic carbonyl compounds to access a wide variety of vinylic sulfones is developed. This reaction works in aqueous media under very mild conditions. This reaction is atom economic. A wide variety of vinylic sulfones could be obtained in moderate to excellent yields with wide functional group tolerance. The efficiency of this method is demonstrated in some reactions where the desired products can be isolated by filtration.