Hemangioblastoma: An Unsuspected Pitfall in PSMA PET/CT

Clin Nucl Med. 2021 Jun 1;46(6):485-487. doi: 10.1097/RLU.0000000000003511.


Hemangioblastoma (HB) is the most common primary intra-axial posterior fossa tumor in adults and is a benign vascular neoplasm. We report the case of a 73-year-old man suffering from biochemical recurrence of prostate cancer where intense overexpression of prostate-specific membrane antigen (PSMA) was observed in HB in a PSMA PET/CT. Overexpression of PSMA in tumor-associated vascular structures has been proposed as an explanation of PSMA ligand uptake in several nonprostatic tumors. Given the pathological nature of HB, this mechanism may explain the intense overexpression of PSMA observed in present case.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antigens, Surface / metabolism*
  • Cerebellar Neoplasms / diagnostic imaging*
  • Cerebellar Neoplasms / metabolism
  • Cerebellar Neoplasms / pathology
  • Gene Expression Regulation, Neoplastic
  • Glutamate Carboxypeptidase II / metabolism*
  • Hemangioblastoma / diagnostic imaging*
  • Hemangioblastoma / metabolism
  • Hemangioblastoma / pathology
  • Humans
  • Male
  • Positron Emission Tomography Computed Tomography*


  • Antigens, Surface
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II