Resveratrol supplementation and acute pancreatitis: A comprehensive review

Biomed Pharmacother. 2021 May;137:111268. doi: 10.1016/j.biopha.2021.111268. Epub 2021 Jan 22.


Resveratrol, a natural polyphenolic ingredient extracted from herbs, suppresses oxidative stress and inflammation. We performed a comprehensive review to find any evidence about the effects of Resveratrol on acute pancreatitis (AP). Resveratrol has been found to directly impact cytokine generation. As these factors play a crucial role in the pathophysiology of AP, resveratrol might attenuate AP and its complications. Mechanistically, resveratrol exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. Indeed, resveratrol might prove to be an effective therapeutic component for AP treatment in the future. In this review, we shed light on potential most recent pathways through which resveratrol might impact the management and control of AP.

Keywords: Acute pancreatitis; Inflammation; Oxidative stress; Resveratrol.

Publication types

  • Review