Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

Cell. 1988 Mar 25;52(6):925-33. doi: 10.1016/0092-8674(88)90434-5.


Intercellular adhesion molecule 1 (ICAM-1) is a 90 kd inducible surface glycoprotein that promotes adhesion in immunological and inflammatory reactions. ICAM-1 is a ligand of lymphocyte function-associated antigen-1 (LFA-1), an alpha beta complex that is a member of the integrin family of cell-cell and cell-matrix receptors. ICAM-1 is encoded by an inducible 3.3 kb mRNA. The amino acid sequence specifies an integral membrane protein with an extracellular domain of 453 residues containing five immunoglobulin-like domains. Highest homology is found with neural cell adhesion molecule (NCAM) and myelin-associated glycoprotein (MAG), which also contain five Ig-like domains. NCAM and MAG are nervous system adhesion molecules, but unlike ICAM-1, NCAM is homophilic. The ICAM-1 and LFA-1 interaction is heterophilic and unusual in that it is between members of the immunoglobulin and intergrin families. Unlike other integrin ligands, ICAM-1 does not contain an RGD sequence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antigens, Surface / genetics*
  • Base Sequence
  • Cell Adhesion Molecules
  • Cloning, Molecular
  • Genes*
  • Genes, Immunoglobulin*
  • Humans
  • Immunoglobulins / genetics*
  • Leukemia, Hairy Cell / genetics
  • Leukemia, Hairy Cell / immunology
  • Lymphocytes / immunology
  • Lymphocytes / metabolism
  • Membrane Glycoproteins / genetics*
  • Molecular Sequence Data
  • RNA, Messenger / genetics


  • Antigens, Surface
  • Cell Adhesion Molecules
  • Immunoglobulins
  • Membrane Glycoproteins
  • RNA, Messenger

Associated data

  • GENBANK/J03132