The half-lives of serum immunoglobulins in adult mice

Eur J Immunol. 1988 Feb;18(2):313-6. doi: 10.1002/eji.1830180221.


We determined the half-lives of several sets of murine monoclonal antibodies spanning all immunoglobulin isotypes in the serum. The antibodies in each set possess the same V region. With this approach, the differences in half-life observed between the different isotypes are independent of the V region carried by the monoclonal antibodies and therefore must relate to each other in the same way as the half-lives of each class of serum immunoglobulins. The half-life of a monoclonal antibody of the gamma 2a isotype is identical to the average half-life of serum IgG2a as previously determined (6-8 days; P. Vieira and K. Rajewsky, Eur. J. Immunol. 1986. 16:871). Therefore, the half-lives determined with monoclonal antibodies possessing the same V region represent the half-life of the serum immunoglobulins. In this way we calculated the half-life of IgM as 2 days, IgG3 and IgG1 as 6-8 days, IgG2b has a half-life of 4-6 days. IgE has a half-life of 12 h. A polymeric form of IgA was found to be eliminated from the serum with a half-life of 17-22 h.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Animals
  • Antibodies, Monoclonal / analysis
  • Female
  • Half-Life
  • Haptens / immunology
  • Immunoglobulin G / metabolism
  • Immunoglobulin Idiotypes / immunology
  • Immunoglobulin Isotypes / metabolism
  • Immunoglobulins / metabolism*
  • Immunoglobulins / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Nitrophenols / immunology
  • Phenylacetates


  • Antibodies, Monoclonal
  • Haptens
  • Immunoglobulin G
  • Immunoglobulin Idiotypes
  • Immunoglobulin Isotypes
  • Immunoglobulins
  • Nitrophenols
  • Phenylacetates
  • 4-hydroxy-5-nitrophenyl acetic acid