Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar

J Am Coll Cardiol. 2021 Feb 2;77(4):423-436. doi: 10.1016/j.jacc.2020.09.619.


This is an update of the previous 2018 systematic review and meta-analysis of vitamin and mineral supplementation on cardiovascular disease outcomes and all-cause mortality. New randomized controlled trials and meta-analyses were identified by searching the Cochrane library, Medline, and Embase, and data were analyzed using random effects models and classified by the Grading of Recommendations Assessment Development and Evaluation approach. This updated review shows similar findings to the previous report for preventive benefits from both folic acid and B vitamins for stroke and has been graded with moderate quality. No effect was seen for the commonly used multivitamins, vitamin D, calcium, and vitamin C, and an increased risk was seen with niacin (with statin) for all-cause mortality. Conclusive evidence for the benefit of supplements across different dietary backgrounds, when the nutrient is sufficient, has not been demonstrated.

Keywords: all-cause mortality; cardiovascular disease; meta-analysis; supplements.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Cardiovascular Diseases / prevention & control*
  • Diet, Vegetarian
  • Dietary Supplements*
  • Humans
  • Stroke / prevention & control
  • Vitamin B Complex / therapeutic use


  • Vitamin B Complex

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