Bayesian spatial modeling of transfusion-dependent β-thalassemia incidence rate in Fars Province, Southern Iran

Sezaneh Haghpanah; Naeimehossadat Asmarian; Omid Reza Zekavat; Mohammadreza Bordbar; Mehran Karimi; Soheila Zareifar; Mani Ramzi; Sanaz Safaei

doi:10.1016/j.sste.2020.100389

Bayesian spatial modeling of transfusion-dependent β-thalassemia incidence rate in Fars Province, Southern Iran

Spat Spatiotemporal Epidemiol. 2021 Feb:36:100389. doi: 10.1016/j.sste.2020.100389. Epub 2020 Nov 7.

Authors

Sezaneh Haghpanah¹, Naeimehossadat Asmarian², Omid Reza Zekavat¹, Mohammadreza Bordbar¹, Mehran Karimi¹, Soheila Zareifar¹, Mani Ramzi¹, Sanaz Safaei¹

Affiliations

¹ Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
² Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: ns.asmarian@gmail.com.

PMID: 33509421
DOI: 10.1016/j.sste.2020.100389

Abstract

Background: Using maps and spatial analysis are technologies to evaluate the magnitude and spatial distribution of disease in epidemiology investigations. We aimed to conduct a Bayesian spatial analysis on epidemiologic data of transfusion-dependent β-thalassemia (TDT) patients.

Methods: In this cross-sectional study, data of all TDT patients diagnosed during 1955-2018 in all counties of Fars Province were obtained from data registry of the Organization of Special Diseases of Shiraz University of Medical Sciences in Shiraz, Fars Province, Iran. Besag, York, and Mollie's (BYM) model was used for mapping.

Results: The estimated relative risk ranged from 0.23 to 1.66 for TDT patients. The highest and lowest relative risks of TDT were observed in Larestan located in Southern and Abadeh in Northern Fars Province respectively.

Conclusions: Determining the accurate geographical distribution of a chronic disease such as β-thalassemia can be an essential prerequisite in allocation of regional health system resources.

Keywords: Anemia; Iran; Spatial Bayesian analysis; Transfusion; β-thalassemia.

MeSH terms

Bayes Theorem
Cross-Sectional Studies
Humans
Incidence
Iran / epidemiology
beta-Thalassemia* / epidemiology
beta-Thalassemia* / therapy