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Case Reports
. 2021 Jan 28;14(1):e234876.
doi: 10.1136/bcr-2020-234876.

Hyperthermic intraperitoneal chemotherapy (HIPEC) as another treatment modality for desmoplastic round cell tumour patients: first paediatric experience from UK

Tomas Sjoberg Bexelius  1   2 , Julia C Chisholm  3   4 , Bruce Okoye  5 , Tom Cecil  6 , Paola Angelini  3 , Sanjeev Dayal  7
Affiliations
Case Reports

Hyperthermic intraperitoneal chemotherapy (HIPEC) as another treatment modality for desmoplastic round cell tumour patients: first paediatric experience from UK

Tomas Sjoberg Bexelius et al. BMJ Case Rep. .

Abstract

We present the first young paediatric patient with desmoplastic small round cell tumour (DSRCT) treated in UK with hyperthermic intraperitoneal chemotherapy (HIPEC). A 7-year-old girl was diagnosed with abdominal DSRCT with peritoneal and liver metastases. After six cycles of chemotherapy she obtained a partial response, including almost complete resolution of the two liver metastases. It was decided to pursue cytoreductive surgery (CRS) combined with HIPEC, a procedure commonly performed in adults, but seldom in a child. The surgery was macroscopically complete and the HIPEC uncomplicated. She continued treatment without delays, including whole abdomino-pelvic radiotherapy and maintenance chemotherapy (cyclophosphamide/vinorelbine for 12 months). She is currently in complete remission 4 months after end of treatment and 26 months after diagnosis. HIPEC was made possible by successful collaboration between multiple teams. CRS-HIPEC proved to be safe and feasible and could be offered to other children with diagnoses of peritoneal malignancies across the UK.

Keywords: malignant disease and immunosuppression; paediatric oncology; paediatrics (drugs and medicines).

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
MRI at presentation.
Figure 2
Figure 2
Five months since diagnosis: partial response.
Figure 3
Figure 3
Eight months since diagnosis, prior to surgery and hyperthermic intraperitoneal chemotherapy.
Figure 4
Figure 4
Thirty days post surgery and hyperthermic intraperitoneal chemotherapy. Complete remission.
Figure 5
Figure 5
Flow sheet of received treatment. DSRCT, desmoplasticsmallroundcelltumour;HIPEC, hyperthermic intraperitoneal chemotherapy.
See this image and copyright information in PMC

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