Coronavirus Disease 2019 Symptoms and Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Positivity in a Large Survey of First Responders and Healthcare Personnel, May-July 2020

Clin Infect Dis. 2021 Aug 2;73(3):e822-e825. doi: 10.1093/cid/ciab080.


A severe acute respiratory syndrome coronavirus 2 serosurvey among first responder/healthcare personnel showed that loss of taste/smell was most predictive of seropositivity; percent seropositivity increased with number of coronavirus disease 2019 symptoms. However, 22.9% with 9 symptoms were seronegative, and 8.3% with no symptoms were seropositive. These findings demonstrate limitations of symptom-based surveillance and importance of testing.

Keywords: COVID-19 symptom; SARS-CoV-2; first responders; healthcare personnel; seroprevalence.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • COVID-19*
  • Delivery of Health Care
  • Emergency Responders*
  • Humans
  • SARS-CoV-2
  • Seroepidemiologic Studies