Atrial Fibrillation in Inherited Channelopathies

Card Electrophysiol Clin. 2021 Mar;13(1):155-163. doi: 10.1016/j.ccep.2020.10.004. Epub 2021 Jan 8.


Atrial fibrillation (AF), the common sustained arrhythmia in clinical practice, has major public health implications due to its associated morbidity and increased mortality. The AF epidemic is due to the burgeoning elderly population and the identification of novel risk factors, for example, genetics. Since the diagnosis of AF has a major impact on the clinical assessment and management of patients with inherited arrhythmia syndromes, improved understanding of the cause and pathogenesis of AF has provided important insights into the underlying pathophysiological mechanisms of this common arrhythmia and identified potential mechanism-based therapies.

Keywords: Atrial fibrillation; Brugada syndrome; Channelopathies; Early repolarizations; Long QT syndrome; Short QT syndrome.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Arrhythmias, Cardiac
  • Atrial Fibrillation*
  • Channelopathies*
  • Humans