Engineered drug delivery devices to address Global Health challenges

Ilin Sadeghi; James Byrne; Rameen Shakur; Robert Langer

doi:10.1016/j.jconrel.2021.01.035

Engineered drug delivery devices to address Global Health challenges

J Control Release. 2021 Mar 10:331:503-514. doi: 10.1016/j.jconrel.2021.01.035. Epub 2021 Jan 28.

Authors

Ilin Sadeghi¹, James Byrne², Rameen Shakur¹, Robert Langer³

Affiliations

¹ Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
² Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Harvard Radiation Oncology Program, Boston, MA 02114, USA.
³ Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: rlanger@mit.edu.

Abstract

There is a dire need for innovative solutions to address global health needs. Polymeric systems have been shown to provide substantial benefit to all sectors of healthcare, especially for their ability to extend and control drug delivery. Herein, we review polymeric drug delivery devices for vaccines, tuberculosis, and contraception.

Keywords: Contraception; DNA/RNA delivery; Delivery of TB drugs; Drug delivery; Global health challenges; Materials science; Microneedles; Microparticles; Nanoparticles; Polymer science; Polymeric drug delivery; Surface-eroding polymers; Vaccine delivery; Vaccine development.

Publication types

Review

MeSH terms

Drug Delivery Systems
Global Health
Nanoparticles*
Pharmaceutical Preparations*
Polymers
Vaccines*

Substances

Pharmaceutical Preparations
Polymers
Vaccines