Association Between Vitamin D and Resistin in Postmenopausal Females With Altered Bone Health

Sundus Tariq; Saba Tariq; Saba Khaliq; Mukhtiar Baig; Manal Abdulaziz Murad; Khalid Parvez Lone

doi:10.3389/fendo.2020.615440

Association Between Vitamin D and Resistin in Postmenopausal Females With Altered Bone Health

Front Endocrinol (Lausanne). 2021 Jan 15:11:615440. doi: 10.3389/fendo.2020.615440. eCollection 2020.

Authors

Sundus Tariq^{1

2}, Saba Tariq^{3

4}, Saba Khaliq², Mukhtiar Baig⁵, Manal Abdulaziz Murad⁶, Khalid Parvez Lone⁷

Affiliations

¹ Department of Physiology, University Medical & Dental College, The University of Faisalabad, Faisalabad, Pakistan.
² Department of Physiology and Cell Biology, University of Health Sciences, Lahore, Pakistan.
³ Department of Pharmacology and Therapeutics, University of Health Sciences, Lahore, Pakistan.
⁴ Pharmacology and Therapeutics, University Medical & Dental College, The University of Faisalabad, Faisalabad, Pakistan.
⁵ Clinical Biochemistry, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
⁶ Department of Family Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
⁷ Department Physiology and Cell Biology/Metabolic Disorders, University of Health Sciences, Lahore, Pakistan.

Abstract

Background: Resistin is a relatively novel adipokine that has a role in bone remodeling and may regulate bone mineral density (BMD). Vitamin D and adipokines have a dynamic role in the body's various metabolic processes, including bone metabolism, and may alter bone metabolism in relation to each other. This study aimed to investigate the association between vitamin D and serum resistin levels in postmenopausal non-osteoporotic and osteoporotic females.

Methods: This correlational analytical study was conducted on 161 postmenopausal females, divided into two groups, non-osteoporotic and osteoporotic, between 50-70 years. Bone mineral density (BMD) was assessed by dual-energy X-ray absorptiometry (DXA) scan. Serum resistin and vitamin D levels were analyzed by enzyme-linked immunosorbent assay (ELISA) method. Serum calcium, phosphate, and alkaline phosphatase with spectrophotometry. A correlation was checked using spearman's rho correlation coefficient, and multivariate stepwise regression analysis was used to predict serum resistin levels.

Results: Postmenopausal females (n=161) having sufficient, insufficient and deficient levels of vitamin D were 87 (54.0%), 64 (39.8%), and 10 (6.2%), respectively. Lumbar spine BMD (p < 0.001), total hip BMD (p < 0.001), and serum resistin levels (p < 0.001) were significantly different between the two groups. There was a significant negative correlation between serum resistin and vitamin D in postmenopausal females (rho = -0.182, p = 0.021) and osteoporotic group (rho = -0.253, p = 0.019) but non-significant in non-osteoporotic group (rho = -0.077, p = 0.509). Serum vitamin D was found to be independent predictor of serum resistin levels, accounting for only 3% variance.

Conclusion: Serum vitamin D levels were low while serum resistin levels were high in postmenopausal osteoporotic females and vitamin D is a negative predictor of serum resistin levels.

Keywords: bone health; osteoporosis; postmenopausal women; resistin; vitamin D.

MeSH terms

Aged
Bone Density / physiology*
Cross-Sectional Studies
Female
Humans
Middle Aged
Osteoporosis, Postmenopausal / blood*
Osteoporosis, Postmenopausal / diagnosis*
Osteoporosis, Postmenopausal / epidemiology
Postmenopause / blood*
Resistin / blood*
Vitamin D / blood*

Substances

RETN protein, human
Resistin
Vitamin D