Dietary Luteolin: A Narrative Review Focusing on Its Pharmacokinetic Properties and Effects on Glycolipid Metabolism

J Agric Food Chem. 2021 Feb 10;69(5):1441-1454. doi: 10.1021/acs.jafc.0c08085. Epub 2021 Feb 1.


Luteolin, a flavone subclass of flavonoids, is commonly found in food plants and has multiple biological activities. Recently, evidence is growing with regard to the potential of luteolin intake to beneficially affect glycolipid metabolism disorders (GLMDs), particularly insulin resistance, diabetes, and obesity. The aim of this contribution is to provide an overview of recent advances in identifying and understanding the pharmacokinetic properties (absorption, metabolism, and bioavailability) of luteolin, its regulatory effects on glycolipid metabolism, and the underlying mechanisms of action of luteolin in the brain, liver, adipose tissues, and other tissues/organs. Collectively, luteolin or its principal metabolites may contribute to counteracting GLMDs, especially for human obesity and diabetes.

Keywords: glycolipid metabolism; luteolin; mechanisms; pharmacokinetic properties.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / metabolism
  • Glycolipids / metabolism*
  • Humans
  • Luteolin / administration & dosage*
  • Luteolin / pharmacokinetics
  • Obesity / drug therapy*
  • Obesity / metabolism


  • Glycolipids
  • Luteolin