Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival

Am J Otolaryngol. 2021 May-Jun;42(3):102938. doi: 10.1016/j.amjoto.2021.102938. Epub 2021 Jan 28.


Background: Diffuse Large B-Cell Lymphoma (DLBCL) of the major salivary glands is a rare high-grade malignancy that often presents with vague symptoms. This study aimed to evaluate its incidence and prognosis on a population level.

Methods: The Surveillance, Epidemiology, and End Results database was queried for cases of major salivary gland DLBCL.

Results: 896 patients had DLBCL affecting the parotid gland (78.3%) or submandibular gland (19.8%). The incidence was increasing at 1.5% (P = 0.005) per year from 1973 to 2016. 24.4% of patients underwent parotidectomy, 16% had biopsy, and the remaining provided no details of diagnostic method. Five-year disease-specific survival increased from 59.8% to 84.0%. Late-stage disease (HR = 1.7, P = 0.003) and female sex (HR = 2.1, P = 0.018) were associated with increased risk of mortality.

Conclusion: Despite the rising incidence of major salivary gland DLBCL, chemotherapy and radiation treatment has resulted in increasingly favorable survival outcomes. The otolaryngologist - head and neck surgeon continues to play a critical role in establishing the diagnosis of salivary gland DLBCL.

Keywords: Diffuse large B-cell lymphoma; Incidence; SEER; Salivary gland; Survival.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Combined Modality Therapy
  • Female
  • Humans
  • Incidence
  • Lymphoma, Large B-Cell, Diffuse / diagnosis
  • Lymphoma, Large B-Cell, Diffuse / epidemiology*
  • Lymphoma, Large B-Cell, Diffuse / mortality
  • Lymphoma, Large B-Cell, Diffuse / therapy*
  • Male
  • Middle Aged
  • Otolaryngologists
  • Otorhinolaryngologic Surgical Procedures / methods
  • Parotid Gland / surgery
  • Parotitis
  • Physician's Role
  • Prognosis
  • Risk Factors
  • Salivary Gland Neoplasms / diagnosis
  • Salivary Gland Neoplasms / epidemiology*
  • Salivary Gland Neoplasms / mortality
  • Salivary Gland Neoplasms / therapy*
  • Sex Factors
  • Survival Rate
  • Young Adult