Sialadenoma Papilliferum

Surg Pathol Clin. 2021 Mar;14(1):43-51. doi: 10.1016/j.path.2020.09.006. Epub 2021 Jan 5.


Sialadenoma papilliferum (SP) is a rare, benign salivary gland neoplasm sharing similar histopathologic features and harboring the same genetic alterations, BRAF V600E or HRAS mutations, with syringocystadenoma papilliferum. SP most commonly occurs in the hard palate and in older adults. Clinically, SP is most likely to be diagnosed as a squamous papilloma. Microscopically, SP shows an exophytic papillary epithelial proliferation and a contiguously endophytic ductal proliferation. Two distinct subtypes are identified: classic SP and oncocytic SP. Conservative surgical treatment seems to be adequate with a low recurrence. SOX10 immunohistochemistry and BRAF analysis may be useful in differential diagnosis.

Keywords: BRAF V600E mutation; Classic; HRAS Q61R mutation; Oncocytic; Sialadenoma papilliferum.

Publication types

  • Review

MeSH terms

  • Adenoma / classification
  • Adenoma / diagnosis
  • Adenoma / pathology*
  • Adenoma / surgery
  • Cell Proliferation
  • Diagnosis, Differential
  • Epithelial Cells / pathology
  • Humans
  • Immunohistochemistry
  • Mutation
  • Palate, Hard / pathology
  • Prognosis
  • Proto-Oncogene Proteins B-raf / genetics
  • SOXE Transcription Factors / analysis
  • Salivary Gland Neoplasms / classification
  • Salivary Gland Neoplasms / diagnosis
  • Salivary Gland Neoplasms / pathology*
  • Salivary Gland Neoplasms / surgery
  • Salivary Glands, Minor / pathology


  • SOX10 protein, human
  • SOXE Transcription Factors
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf