Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome

Int J Med Sci. 2021 Jan 1;18(5):1114-1120. doi: 10.7150/ijms.51545. eCollection 2021.


Bacteria response to their environment by producing some compounds which are used in cosmetic and pharmaceutical applications. Some probiotics can regulate immune response and modulate the symptoms of several diseases. Bacteria affect skin response to skin care products. Bacteria are thought to play an important role in acne incidence, skin moisture, and nutrient metabolism, but only a few studies have focused on the extracts of Lactobacillus plantarum in skin care. In this study, we identified that L. plantarum-GMNL6 enhanced collagen synthesis and the gene expression of serine palmitoyltransferase small subunit A. Meanwhile, L. plantarum-GMNL6 reduced the melanin synthesis, the biofilm of Staphylococcus aureus, and the proliferation of Cutibacterium acnes. Information from clinical observation during the ointment for external face use in people displayed that the syndromes of skin moisture, skin color, spots, wrinkles, UV spots, and porphyrins were improved. The diversification of human skin microbiomes was affected by smearing the face of volunteers with L. plantarum-GMNL6. Understanding the potential mechanisms of the action of L. plantarum-GMNL6 in dermatologic conditions promotes the development of care products.

Keywords: Lactobacillus plantarum-GMNL6; care products; probiotics; skin care.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Animals
  • Biofilms / growth & development
  • Cell Line, Tumor
  • Collagen / biosynthesis
  • Female
  • Fibroblasts
  • Humans
  • Lactobacillus plantarum / immunology*
  • Male
  • Mice
  • Microbiota / immunology*
  • Middle Aged
  • Ointments
  • Probiotics / administration & dosage*
  • Propionibacteriaceae / growth & development
  • Propionibacteriaceae / immunology
  • Propionibacteriaceae / isolation & purification
  • Skin / immunology
  • Skin / metabolism
  • Skin / microbiology*
  • Skin Care / methods*
  • Staphylococcus aureus / growth & development
  • Staphylococcus aureus / immunology
  • Staphylococcus aureus / isolation & purification
  • Treatment Outcome
  • Young Adult


  • Ointments
  • Collagen

Supplementary concepts

  • Cutibacterium acnes subsp. acnes