Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy

Clin Infect Dis. 2021 Feb 1;72(3):495-498. doi: 10.1093/cid/ciaa809.


Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.

Keywords: HIV latency; IPDA; TILDA; integrated HIV; p24.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • CD4-Positive T-Lymphocytes
  • DNA, Viral / genetics
  • HIV Infections* / drug therapy
  • HIV-1* / genetics
  • Humans
  • Proviruses / genetics
  • Virus Latency


  • DNA, Viral