The effect of liver donors' age, gender and metabolic state on pancreatic lineage activation

Regen Med. 2021 Jan;16(1):19-31. doi: 10.2217/rme-2020-0092. Epub 2021 Feb 2.


Autologous cells replacement therapy by liver to pancreas transdifferentiation (TD) allows diabetic patients to be also the donors of their own therapeutic tissue. Aim: To analyze whether the efficiency of the process is affected by liver donors' heterogeneity with regard to age, gender and the metabolic state. Materials & methods: TD of liver cells derived from nondiabetic and diabetic donors at different ages was characterized at molecular and cellular levels, in vitro. Results: Neither liver cells proliferation nor the propagated cells TD efficiency directly correlate with the age (3-60 years), gender or the metabolic state of the donors. Conclusion: Human liver cells derived from a wide array of ages and metabolic states can be used for autologous cells therapies for diabetics.

Keywords: adult cell reprogramming; cell replacement therapy; diabetes; liver; pancreatic transcription factors; transdifferentiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cell Proliferation
  • Cell Transdifferentiation*
  • Child
  • Child, Preschool
  • Humans
  • Liver
  • Middle Aged
  • Pancreas*
  • Young Adult