The multifaceted roles of DNA repair and replication proteins in aging and obesity

Alexandra M D'Amico; Karen M Vasquez

doi:10.1016/j.dnarep.2021.103049

The multifaceted roles of DNA repair and replication proteins in aging and obesity

DNA Repair (Amst). 2021 Mar:99:103049. doi: 10.1016/j.dnarep.2021.103049. Epub 2021 Jan 21.

Authors

Alexandra M D'Amico¹, Karen M Vasquez²

Affiliations

¹ Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Boulevard, Austin, TX, 78723, USA.
² Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Boulevard, Austin, TX, 78723, USA. Electronic address: karen.vasquez@austin.utexas.edu.

Abstract

Efficient mechanisms for genomic maintenance (i.e., DNA repair and DNA replication) are crucial for cell survival. Aging and obesity can lead to the dysregulation of genomic maintenance proteins/pathways and are significant risk factors for the development of cancer, metabolic disorders, and other genetic diseases. Mutations in genes that code for proteins involved in DNA repair and DNA replication can also exacerbate aging- and obesity-related disorders and lead to the development of progeroid diseases. In this review, we will discuss the roles of various DNA repair and replication proteins in aging and obesity as well as investigate the possible mechanisms by which aging and obesity can lead to the dysregulation of these proteins and pathways.

Keywords: Aging; DNA repair; DNA replication; Genetic instability; Obesity.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Aging / genetics
Aging / metabolism*
Animals
DNA Repair*
DNA Replication*
Genomic Instability
Humans
Obesity / genetics
Obesity / metabolism*

Abstract

Publication types

MeSH terms

Grants and funding