Potential therapeutic effect of Chrysopogon zizanioides (Vetiver) as an anti-inflammatory agent

Environ Sci Pollut Res Int. 2021 Apr;28(13):15597-15606. doi: 10.1007/s11356-021-12652-z. Epub 2021 Feb 3.


Vetiver has a broad history of traditional medicinal uses, but only a handful of research article has reported its utility in treating diseases. But unfortunately, no work has been reported on the anti-inflammatory activity of its plant extract and inflammatory-linked diseases. Hence, the present review focuses on investigating the several presumptions which can be put forward to explain its anti-inflammatory property. Thus, for ensuring the same, all the databases like science direct, PubMed, book chapters, and other authenticated papers were thoroughly studied to present a connection between inflammation and the plant potential. After gaining enough knowledge on pathogenesis of inflammation, it has been observed that the release of mediators from the arachidonic acid metabolism pathway and generation of oxidative and nitrogen species are presented as the main reason for the occurrence of inflammation condition. The stimulation of antioxidant enzyme system network by the plant extract reduces the level of oxidative stress, creating a balance between oxidant and antioxidant system. Moreover, its antimicrobial activity will prevent the biological source of stimulation towards injury and the CNS depressant effect will subside the pain of inflammation. Amalgamating all the factors together, the plant can be utilized as anti-inflammatory can be and also can be proved as a beneficial perspective in the treatment of inflammation-linked disorders.

Keywords: Inflammation; Reactive oxygen species; Vetiver; Vetiveria zizanioides; Vetivone.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Antioxidants / pharmacology
  • Biodegradation, Environmental
  • Chrysopogon*
  • Oxidative Stress
  • Plant Extracts / pharmacology


  • Anti-Inflammatory Agents
  • Antioxidants
  • Plant Extracts