An analysis of cocaine effects on locomotor activities and heart rate in four inbred mouse strains

Pharmacol Biochem Behav. 1988 Jan;29(1):157-62. doi: 10.1016/0091-3057(88)90289-4.


The effects of cocaine on Y-maze activity and heart rate have been examined in four inbred strains of mouse (BALB, C57BL, C3H and DBA). In addition, brain [3H]-cocaine concentrations were measured at the time of maximal response to cocaine. Cocaine produced a dose-related increase in Y-maze cross activity in C3H, DBA and C57BL, with C3H mice being considerably more sensitive than DBA or C57BL. Cocaine was without effect on Y-maze cross activity in BALB mice. Cocaine produced a biphasic effect on rearing activity in C3H mice, a dose related depression in BALB mice, and was without effect on C57BL and DBA mice. At the highest dose studied (15 mg/kg), cocaine produced a small decrease in heart rate in C3H mice. Strain differences in behavior were maximal 15 minutes after a dose of 5 mg/kg, IP. At this dose and time interval, brain [3H]-cocaine concentrations were not significantly different among the four strains of mice. The results suggest a genetically-determined difference in CNS sensitivity to cocaine.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Chemistry / drug effects
  • Cocaine / pharmacokinetics
  • Cocaine / pharmacology*
  • Dose-Response Relationship, Drug
  • Heart Rate / drug effects*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Motor Activity / drug effects*
  • Species Specificity


  • Cocaine