Mass spectrometry techniques for imaging and detection of metallodrugs

Curr Opin Chem Biol. 2021 Apr:61:123-134. doi: 10.1016/j.cbpa.2020.12.005. Epub 2021 Jan 31.

Abstract

Undoubtedly, metallomic approaches based on mass spectrometry have evolved into essential tools supporting the drug development of novel metal-based anticancer drugs. This article will comment on the state-of-the-art instrumentation and highlight some of the recent analytical advances beyond routine, especially focusing on the latest developments in inductively coupled plasma-mass spectrometry (ICP-MS). Mass spectrometry-based bioimaging and single-cell methods will be presented, paving the way to exciting investigations of metal-based anticancer drugs in heterogeneous and structurally, as well as functionally complex solid tumor tissues.

Keywords: Imaging mass spectrometry; Laser ablation-ICP-MS; Metallodrug development; Metallomics; Single-cell analysis.

Publication types

  • Review

MeSH terms

  • Humans
  • Mass Spectrometry / methods*
  • Metals / chemistry*
  • Pharmaceutical Preparations / chemistry*

Substances

  • Metals
  • Pharmaceutical Preparations