Re-irradiation of mouse skin: similarity of dose reductions for healing and macrocolony endpoints

Radiother Oncol. 1988 Feb;11(2):153-9. doi: 10.1016/0167-8140(88)90251-4.

Abstract

The amount of residual injury in mouse tail skin, assessed by the decrease in re-irradiation dose for equal effect, was similar whether assessed using healing or colony endpoints (17-21% after single priming doses). There were tendencies towards an increased sensitivity of the colony-forming cells by a factor of about 2, and less residual injury after multifractionated priming doses. These observations are compatible with a lower alpha/beta ratio characterising the response to dose fractionation for residual injury than for the acute healing response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival
  • Dose-Response Relationship, Radiation
  • Female
  • Mice
  • Mice, Inbred Strains
  • Necrosis
  • Skin / cytology
  • Skin / radiation effects*
  • Stem Cells / radiation effects
  • Wound Healing