Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2021 Feb 3;21(1):69.
doi: 10.1186/s12872-020-01835-0.

Lipid profile and prognosis in patients with coronary heart disease: a meta-analysis of prospective cohort studies

Xiangmei Zhao  1 , Dongying Wang  2 , Lijie Qin  3
Affiliations
Meta-Analysis

Lipid profile and prognosis in patients with coronary heart disease: a meta-analysis of prospective cohort studies

Xiangmei Zhao et al. BMC Cardiovasc Disord. .

Abstract

Background: This meta-analysis based on prospective cohort studies aimed to evaluate the associations of lipid profiles with the risk of major adverse cardiovascular outcomes in patients with coronary heart disease (CHD).

Methods: The PubMed, Embase, and Cochrane Library electronic databases were systematically searched for prospective cohort study published through December 2019, and the pooled results were calculated using the random-effects model.

Results: Twenty-one studies with a total of 76,221 patients with CHD met the inclusion criteria. The per standard deviation (SD) increase in triglyceride was associated with a reduced risk of major adverse cardiovascular events (MACE). Furthermore, the per SD increase in high-density lipoprotein cholesterol (HDL-C) was associated with a reduced risk of cardiac death, whereas patients with lower HDL-C were associated with an increased risk of MACE, all-cause mortality, and cardiac death. Finally, the risk of MACE was significantly increased in patients with CHD with high lipoprotein(a) levels.

Conclusions: The results of this study suggested that lipid profile variables could predict major cardiovascular outcomes and all-cause mortality in patients with CHD.

Keywords: Cardiovascular infections; Coronary disease; Lipids; Meta-analysis; Prognosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the literature search and study selection
Fig. 2
Fig. 2
Summarized results with respect to the role of lipid profile variables on the risk of major cardiovascular events, all-cause mortality, and cardiac death in patients with coronary heart disease
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. WHO . The top 10 causes of death. Geneva: World Health Organisation; 2019.
    1. Antithrombotic TC. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ (Clin Res Ed) 2002;324(7329):71–86. doi: 10.1136/bmj.324.7329.71. - DOI - PMC - PubMed
    1. Ettehad D, Emdin CA, Kiran A, Anderson SG, Callender T, Emberson J, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet (London, England) 2016;387(10022):957–967. doi: 10.1016/S0140-6736(15)01225-8. - DOI - PubMed
    1. Chou R, Dana T, Blazina I, Daeges M, Jeanne TL. Statins for prevention of cardiovascular disease in adults: evidence report and systematic review for the US preventive services task force. JAMA. 2016;316(19):2008–2024. doi: 10.1001/jama.2015.15629. - DOI - PubMed
    1. Karimi F, Rayani M, Akbarzade S, Tahmasebi R, Khakzade M, Arab J. The prevalence of hyperlipidemia in persons over 19 years of Bushehr in 1378. Iran South Med J. 2000;3(2):98–106.

Publication types

LinkOut - more resources