Abstract
Pin1 belongs to the peptidyl-prolyl cis-trans isomerases (PPIases) superfamily and catalyzes the cis-trans conversion of proline in target substrates to modulate diverse cellular functions including cell cycle progression, cell motility, and apoptosis. Dysregulation of Pin1 has wide-ranging influences on the fate of cells; therefore, it is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
Keywords:
Pin1; neurodegenerative diseases; pathogenesis of diseases; peptidyl-prolyl cis-trans isomerases; viral infection.
© The author(s).
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Apoptosis / genetics
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Cardiovascular Diseases / genetics*
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / pathology
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Cell Cycle / genetics
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Cell Movement
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Diabetes Mellitus, Type 2 / genetics*
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Diabetes Mellitus, Type 2 / metabolism
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Diabetes Mellitus, Type 2 / pathology
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Gene Expression Regulation
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Humans
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NIMA-Interacting Peptidylprolyl Isomerase / genetics*
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NIMA-Interacting Peptidylprolyl Isomerase / metabolism
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Neoplasm Proteins / genetics
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Neoplasm Proteins / metabolism
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Neoplasms / genetics*
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Neoplasms / metabolism
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Neoplasms / pathology
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Neovascularization, Pathologic / genetics*
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Neovascularization, Pathologic / metabolism
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Neovascularization, Pathologic / pathology
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Neurodegenerative Diseases / genetics*
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Neurodegenerative Diseases / metabolism
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Neurodegenerative Diseases / pathology
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Obesity / genetics*
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Obesity / metabolism
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Obesity / pathology
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Signal Transduction
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Virus Diseases / genetics*
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Virus Diseases / metabolism
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Virus Diseases / pathology
Substances
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NIMA-Interacting Peptidylprolyl Isomerase
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Neoplasm Proteins
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PIN1 protein, human