Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial

doi:10.1001/jamaoto.2020.5490

Randomized Controlled Trial

. 2021 Apr 1;147(4):400-401.

doi: 10.1001/jamaoto.2020.5490.

Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial

Jeremy Guenezan¹, Magali Garcia², Deidre Strasters¹, Clément Jousselin², Nicolas Lévêque², Denis Frasca³, Olivier Mimoz¹

Affiliations

¹ Emergency Department, University Hospital of Poitiers, Poitiers, France.
² Virology laboratory, University Hospital of Poitiers, Poitiers, France.
³ Department of Anesthesia, Intensive Care and Perioperative Medicine, University Hospital of Poitiers, Poitiers, France.

PMID: 33538761
PMCID: PMC7863011
DOI: 10.1001/jamaoto.2020.5490

Randomized Controlled Trial

Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial

Jeremy Guenezan et al. JAMA Otolaryngol Head Neck Surg. 2021.

. 2021 Apr 1;147(4):400-401.

doi: 10.1001/jamaoto.2020.5490.

Authors

Jeremy Guenezan¹, Magali Garcia², Deidre Strasters¹, Clément Jousselin², Nicolas Lévêque², Denis Frasca³, Olivier Mimoz¹

Affiliations

¹ Emergency Department, University Hospital of Poitiers, Poitiers, France.
² Virology laboratory, University Hospital of Poitiers, Poitiers, France.
³ Department of Anesthesia, Intensive Care and Perioperative Medicine, University Hospital of Poitiers, Poitiers, France.

PMID: 33538761
PMCID: PMC7863011
DOI: 10.1001/jamaoto.2020.5490

Abstract

This randomized clinical trial investigates the efficacy of nasopharyngeal povidone iodine solutions in reducing the viral load of patients with COVID-19.

Trial registration: ClinicalTrials.gov NCT04371965.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Mimoz reported receiving grants from Becton Dickinson and Cooper, and personal fees from Becton Dickinson, Cooper, and 3M, all outside the submitted work. No other disclosures were reported.

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Comment in

Regarding Use of Povidone Iodine to Reduce Nasopharyngeal Viral Load in Patients With COVID-19.
Singh A, Yadav M, Sikka K. Singh A, et al. JAMA Otolaryngol Head Neck Surg. 2021 Jul 1;147(7):680-681. doi: 10.1001/jamaoto.2021.0683. JAMA Otolaryngol Head Neck Surg. 2021. PMID: 33914069 No abstract available.

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Efficacy of povidone-iodine nasal rinse and mouth wash in COVID-19 management: a prospective, randomized pilot clinical trial (povidone-iodine in COVID-19 management).
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References

1. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): A Review. JAMA. 2020;324(8):782-793. doi:10.1001/jama.2020.12839 - DOI - PubMed
1. Frank S, Brown SM, Capriotti JA, Westover JB, Pelletier JS, Tessema B. In vitro efficacy of a povidone-iodine nasal antiseptic for rapid inactivation of SARS-CoV-2. JAMA Otolaryngol Head Neck Surg. 2020;146(11):1-5. doi:10.1001/jamaoto.2020.3053 - DOI - PMC - PubMed
1. Etievant S, Bal A, Escuret V, et al. . Performance assessment of SARS-CoV-2 PCR assays developed by WHO referral laboratories. J Clin Med. 2020;9(6):1871. doi:10.3390/jcm9061871 - DOI - PMC - PubMed
1. Kärber, G. Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Archiv f experiment Pathol u Pharmakol. 1934;162:480-483.
1. Farrell NF, Klatt-Cromwell C, Schneider JS. Benefits and safety of nasal saline irrigations in a pandemic—washing COVID-19 away. JAMA Otolaryngol Head Neck Surg. 2020;146(9):787-788. doi:10.1001/jamaoto.2020.1622 - DOI - PubMed

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[1] Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): A Review. JAMA. 2020;324(8):782-793. doi:10.1001/jama.2020.12839 - DOI - PubMed

[2] Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): A Review. JAMA. 2020;324(8):782-793. doi:10.1001/jama.2020.12839 - DOI - PubMed

[3] Frank S, Brown SM, Capriotti JA, Westover JB, Pelletier JS, Tessema B. In vitro efficacy of a povidone-iodine nasal antiseptic for rapid inactivation of SARS-CoV-2. JAMA Otolaryngol Head Neck Surg. 2020;146(11):1-5. doi:10.1001/jamaoto.2020.3053 - DOI - PMC - PubMed

[4] Frank S, Brown SM, Capriotti JA, Westover JB, Pelletier JS, Tessema B. In vitro efficacy of a povidone-iodine nasal antiseptic for rapid inactivation of SARS-CoV-2. JAMA Otolaryngol Head Neck Surg. 2020;146(11):1-5. doi:10.1001/jamaoto.2020.3053 - DOI - PMC - PubMed

[5] Etievant S, Bal A, Escuret V, et al. . Performance assessment of SARS-CoV-2 PCR assays developed by WHO referral laboratories. J Clin Med. 2020;9(6):1871. doi:10.3390/jcm9061871 - DOI - PMC - PubMed

[6] Etievant S, Bal A, Escuret V, et al. . Performance assessment of SARS-CoV-2 PCR assays developed by WHO referral laboratories. J Clin Med. 2020;9(6):1871. doi:10.3390/jcm9061871 - DOI - PMC - PubMed

[7] Kärber, G. Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Archiv f experiment Pathol u Pharmakol. 1934;162:480-483.

[8] Kärber, G. Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Archiv f experiment Pathol u Pharmakol. 1934;162:480-483.

[9] Farrell NF, Klatt-Cromwell C, Schneider JS. Benefits and safety of nasal saline irrigations in a pandemic—washing COVID-19 away. JAMA Otolaryngol Head Neck Surg. 2020;146(9):787-788. doi:10.1001/jamaoto.2020.1622 - DOI - PubMed

[10] Farrell NF, Klatt-Cromwell C, Schneider JS. Benefits and safety of nasal saline irrigations in a pandemic—washing COVID-19 away. JAMA Otolaryngol Head Neck Surg. 2020;146(9):787-788. doi:10.1001/jamaoto.2020.1622 - DOI - PubMed

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Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial

Affiliations

Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial

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