The Ups and Downs of Firing Rate Homeostasis

R Irene Jacobsen; Tara Keck

doi:10.1016/j.neuron.2020.12.024

The Ups and Downs of Firing Rate Homeostasis

Neuron. 2021 Feb 3;109(3):401-403. doi: 10.1016/j.neuron.2020.12.024.

Authors

R Irene Jacobsen¹, Tara Keck²

Affiliations

¹ Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres gate 9, 7030 Trondheim, Norway.
² Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University St., London WC1E 6DE, UK. Electronic address: t.keck@ucl.ac.uk.

PMID: 33539775
DOI: 10.1016/j.neuron.2020.12.024

Abstract

Torrado Pacheco et al. demonstrate that downward firing rate homeostasis occurs when cellular activity levels increase beyond baseline, but only during sleep-dense periods. In contrast, Hebbian-facilitated changes in firing rate occur independently of sleep and wake states.

Publication types

Comment

MeSH terms

Action Potentials
Homeostasis
Neurons*
Sleep
Wakefulness*

Grants and funding

212264/Z/18/Z/WT_/Wellcome Trust/United Kingdom