Human ultra-weak photon emission as non-invasive spectroscopic tool for diagnosis of internal states - A review

J Photochem Photobiol B. 2021 Mar:216:112141. doi: 10.1016/j.jphotobiol.2021.112141. Epub 2021 Jan 28.


In the knowledge that human ultra-weak photon emission (UPE) is mainly due to the metabolic oxidative stress processes that the skin cells undergo in the presence of reactive oxygen species (ROS), external stressors (like UV radiation), but also internal stressors (like diseases or brain activity) might strongly influence the UPE. This manuscript revises the scientific advances focused on the influence of internal factors on the human UPE. According to literature, the UPE seems to be influenced by some diseases (including diabetes, hemiparesis, protoporphyria, or a typical cold), and even by the cerebral intention/relaxation (brain activity/meditation). These allow to consider UPE as a natural and promising non-invasive spectroscopic tool for helping during the diagnosis of a variety of illnesses or stress- / mood-state disorders. Nonetheless, further research is required for answering some still unresolved controversial points.

Keywords: Applications; Bioluminescence; Diagnosis; Human biophoton emission or ultra-weak photon emission (UPE); Internal states; Spectroscopy.

Publication types

  • Review

MeSH terms

  • Brain
  • Diabetes Mellitus / diagnosis
  • Humans
  • In Vitro Techniques
  • Luminescent Measurements / methods*
  • Meditation
  • Paresis / diagnosis
  • Photons
  • Reactive Oxygen Species / metabolism
  • Skin
  • Ultraviolet Rays


  • Reactive Oxygen Species