A phase II clinical trial of flutamide in the treatment of advanced breast cancer

Tumori. 1988 Feb 29;74(1):53-6.

Abstract

An antiandrogenic agent flutamide was used in the treatment of one male and 14 female postmenopausal breast cancer patients. Only a mild and transient response was seen in 2 female patients. Therefore, flutamide cannot be used solely in the treatment of female postmenopausal breast cancer.

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bone Marrow Diseases / chemically induced
  • Breast Neoplasms / drug therapy*
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects
  • Drug Evaluation
  • Female
  • Fluorouracil / administration & dosage
  • Fluorouracil / adverse effects
  • Humans
  • Injections, Intravenous
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects
  • Nausea / chemically induced
  • Pilot Projects
  • Vomiting / chemically induced

Substances

  • Cyclophosphamide
  • Fluorouracil
  • Methotrexate